Intrathecal Veratridine Administration Increases Minimum Alveolar Concentration in Rats
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چکیده
منابع مشابه
Intrathecal administration of N-methyl-D-aspartate receptor antagonist reduces the minimum alveolar anaesthetic concentration of isoflurane in rats.
We have studied the effect of intrathecal administration of N-methyl-D-aspartate (NMDA) receptor antagonists on the minimum alveolar anaesthetic concentration (MAC) of isoflurane in rats. In Wistar rats fitted with indwelling intrathecal catheters, we determined the MAC of isoflurane after administration of a competitive NMDA receptor antagonist, APV (0.01, 0.1, 1.0, 10, 30 micrograms), a non-c...
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BACKGROUND Glutamate transporters [also named excitatory amino acid transporters (EAATs)] bind and take up extracellular glutamate, a major excitatory neurotransmitter, and can regulate glutamatergic neurotransmission in synapses. As anaesthesia is proposed to be induced by enhancing inhibitory neurotransmission, inhibiting excitatory neurotransmission, or both we hypothesize that inhibition of...
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Minimum alveolar concentration (MAC), served as the vital concept for standard measure of potency for inhaled volatile anesthetic agents, has been employed in anesthetic practice for more than 50 years. A re-consideration in the connotation and influence factors on MAC is introduced in this article. MAC actually indicates “median effective dose (ED50) for immobility”, but it is at least not com...
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BACKGROUND Fentanyl decreases the minimum alveolar concentration (MAC) of inhaled anaesthetics and has been used clinically to reduce the requirements of other anaesthetic drugs in humans and small animals. We hypothesized that i.v. fentanyl would decrease the MAC of isoflurane in horses in a dose-dependent manner. METHODS Following determination of baseline MAC of isoflurane, fentanyl was ad...
متن کاملEffects of tramadol on minimum alveolar concentration (MAC) of isoflurane in rats.
It has been suggested previously that tramadol increases central nervous system activity and 'lightens' anaesthesia with volatile agents. We assessed the effects of tramadol on the minimum alveolar concentration (MAC) of isoflurane in 56 Wistar rats, instrumented chronically with an arterial and central venous catheter. The MAC of isoflurane was determined using the tail clamp method under thre...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2008
ISSN: 0003-2999
DOI: 10.1213/ane.0b013e3181815fbc